Buy KPV Peptide

This anti-inflammatory KPV peptide is a cutting-edge tool for researchers in immunology, gastroenterology, and dermatology. KPV (Lysine-Proline-Valine) is a tripeptide that represents the active, C-terminal fragment of α-Melanocyte-Stimulating Hormone (α-MSH). The isolation of this fragment is a prime example of modern peptide science, harnessing the potent immunomodulatory effects of a larger hormone into a small, stable, and highly specific molecule.

While α-MSH has pleiotropic effects, including stimulating pigmentation, KPV was specifically identified and is now synthesized for its targeted anti-inflammatory action. Our high-purity KPV provides a reliable and consistent reagent for investigating inflammatory processes in a wide range of preclinical models. This product is intended strictly for in-vitro and laboratory research applications.

The Targeted Immunomodulation of Our Anti-Inflammatory KPV Peptide

The scientific value of KPV lies in its potent ability to quell inflammatory responses through direct intracellular action. Our commitment to providing a >99% pure product ensures that researchers can study these sensitive pathways with confidence.

Mechanism of Action: Suppressing Pro-Inflammatory Pathways

The primary mechanism of our anti-inflammatory KPV peptide is its ability to modulate key signaling cascades within immune and epithelial cells.

Inhibition of NF-κB: KPV has been shown to enter the cell nucleus and inhibit the activation of Nuclear Factor-kappa B (NF-κB). NF-κB is a master transcription factor that orchestrates the genetic expression of numerous pro-inflammatory cytokines.

Reduction of Inflammatory Cytokines: By suppressing NF-κB and other inflammatory pathways (like MAP kinase), KPV leads to a significant reduction in the production of key inflammatory mediators such as Tumor Necrosis Factor-alpha (TNF-α), Interleukin-6 (IL-6), and Interleukin-1 beta (IL-1β).

Key Distinction from α-MSH

A critical advantage of using KPV for research is its specificity. Unlike the full α-MSH hormone, the anti-inflammatory KPV peptide:

Does Not Induce Pigmentation: It does not significantly activate the Melanocortin 1 Receptor (MC1R), which is responsible for stimulating melanin production. This allows for the study of its anti-inflammatory effects in isolation, without the confounding variable of melanogenesis.

Broad Applications in Inflammation Research

The stability and potent action of KPV make it an ideal candidate for a variety of research models:

Gastroenterology: A key tool in preclinical models of Inflammatory Bowel Disease (IBD), such as chemically induced colitis, to study its effects on reducing gut inflammation and promoting mucosal healing.

Dermatology: Used in topical formulations for research on inflammatory skin conditions like psoriasis, atopic dermatitis (eczema), and rosacea.

Wound Healing: Investigating its ability to modulate the inflammatory phase of wound healing to potentially reduce scarring and improve tissue repair.

Ocular Inflammation: Used in models of uveitis to study its potential to reduce inflammation within the eye.

IMPORTANT LEGAL DISCLAIMER: This product is intended for laboratory research purposes ONLY. It is not for human or veterinary use. It is not a drug, dietary supplement, or cosmetic and is not intended to diagnose, treat, cure, or prevent any disease. It must be handled only by qualified professionals in a controlled research setting.

 

FAQs (Frequently Asked Questions)

What is KPV?

KPV is the tripeptide Lysine-Proline-Valine. It is the active, C-terminal fragment of the α-Melanocyte-Stimulating Hormone (α-MSH) and is primarily researched for its potent anti-inflammatory properties.

What makes KPV an “anti-inflammatory peptide”?

KPV exerts its anti-inflammatory effects by entering cells and inhibiting master inflammatory signaling pathways, most notably NF-κB. This leads to a decreased production of pro-inflammatory cytokines, effectively dampening the inflammatory response at a molecular level.

How does KPV differ from its parent hormone, α-MSH?

The key difference is specificity. KPV contains the anti-inflammatory properties of α-MSH but lacks the part of the hormone that stimulates skin pigmentation (melanogenesis). This makes it a more targeted tool for studying inflammation without this confounding effect.

What is the purity of your anti-inflammatory KPV peptide?

Our anti-inflammatory KPV peptide is guaranteed to have a purity level exceeding 99%, as verified by High-Performance Liquid Chromatography (HPLC) for every batch. A Certificate of Analysis is available.

What is the amino acid sequence of KPV?

The amino acid sequence is Lys-Pro-Val.

Is this product intended for human use to treat inflammation?

Absolutely not. This product is a chemical compound sold strictly for in-vitro and laboratory research. It is not an approved drug or medical treatment and must not be used on humans or animals.

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